Secretory Phospholipase A2, Type IIA, A Biomarker of Septic Arthritis In Children With Joint Irritability

نویسندگان

  • Irma T. Ugalde
  • Halim Hennes
  • Douglas Baker
چکیده

Cite this article: Ugalde IT, Hennes H, Copley L, Huang R, Baker MD (2014) Secretory Phospholipase A2, Type IIA, A Biomarker of Septic Arthritis In Children With Joint Irritability. Ann Orthop Rheumatol 2(3): 1021. *Corresponding author Ugalde, Pediatrics Section of Emergency Medicine, Department of Pediatrics, Baylor College of Medicine, 6621 Fannin St. A.2210, Houston, TX 77030, Tel: 832-8246525; Fax: 832-825-5424; Email: [email protected]

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Clinical and Laboratory Symptoms of Septic Arthritis among Children Hospitalized in Imam Reza Hospital of Mashhad, Iran

  Background   Septic arthritis is an acute infection of the joint space and a pediatric emergency. Delay in proper diagnosis and treatment, while prolonging the course of treatment, can have serious complications. The present study aimed to assess the clinical and laboratory profile of septic arthritis among patients hospitalized in the pediatric war...

متن کامل

Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis

INTRODUCTION Previously, secretory phospholipase A2 (sPLA2) inhibition has been used as an adjunct to conventional rheumatoid arthritis therapy in human clinical trials without significant improvement of arthritic pathology. In this study, we compared the efficacy of a potent and orally active group IIa secretory phospholipase A2 inhibitor (sPLA2I) to conventional anti-arthritic agents; inflixi...

متن کامل

Inflammation and atherosclerosis: Group IIa and Group V sPLA2 are not redundant.

The secretory phospholipase A2 (sPLA2) family hydrolyzes glycerophospholipids at the sn-2 position to generate lysophospholipids and free fatty acids. Ten members have been described in mammals. These enzymes must be clearly distinguished from the intracellular phospholipase A2s that are involved in intracellular signaling. They are also distinct from lipoprotein-associated phospholipase A2 (Lp...

متن کامل

Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice

INTRODUCTION Secretory phospholipase A2 (sPLA2) and matrix metalloproteinase (MMP) inhibitors are potent modulators of inflammation with therapeutic potential, but have limited efficacy in rheumatoid arthritis (RA). The objective of this study was to understand the inhibitory mechanism of phospholipase inhibitor from python (PIP)-18 peptide in cultured synovial fibroblasts (SF), and to evaluate...

متن کامل

Inflammation-associated changes in lipid composition and the organization of the erythrocyte membrane

BACKGROUND Reduced erythrocyte survival and deformability may contribute to the so-called anemia of inflammation observed in septic patients. Erythrocyte structure and function are affected by both the membrane lipid composition and the organization. We therefore aimed to determine whether these parameters are affected during systemic inflammation. METHODS A sensitive matrix-assisted laser de...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014